Nanotechnology is considered as one of the greatest discoveries in the field of science, which has the potential for path-breaking implications in various sectors including health care. This technology aims to drive innovation and invention from the molecular level, with point of application limited only by current technological possibilities and overall imagination.
This scientific breakthrough, according to experts from various fields, will soon be omnipresent and imperative in almost every known industrial sector, especially in healthcare wherein it can be implemented to diagnose and cure diseases that develop on a molecular scale, such as cancer.
The market of nanotechnology in India is expected to attain a market size of $ 2231 Million with a compounded annual growth rate (CAGR) of 10.5%.
How is nanotechnology crucial in developing a cure for cancer?
Nanoscale devices scale in at one hundredth to ten-thousandth times of human cells. If the diameter of such devices is as low as 50 nanometres, they are capable to access the surface of cells and pass through blood vessels. In lower diameters, these devices can gain entry to cells, move through the bloodstream, and into affected organs and specifically detailed areas.
The emergence of nanotechnology in India has allowed Indian medical practitioners and microbiologists to develop treatments and drugs at cost-effective methods. This has facilitated a greater influx of medical tourists from less-privileged countries and also allowed Indian patients to seek cancer treatment in India.
An outlook on the various stages of cancer treatment is provided below for you to develop an idea of how nanotechnology’s unique functionality can be used to cure cancer –
Assembly at the tumour site
A cancer drug facilitates nanoscale devices to assemble specifically at the site of the tumour without affecting any nearby regions still unaffected. Through the EPR (Enhanced Permeability and Retention) effect, passive congregation of nanodevices carrying the drug becomes possible and has proven to work effectively in cases of tumour growth.
A large number of drugs rely on the efficacy of EPR to achieve promising results. Along with the EPR effect, healthcare also needs a long delivery system for the drug to reach sufficiently to the affected region. If you need the drug to stay longer in the blood, you can cover the nano-drugs with water-soluble polymers.
The EPR effect can also be artificially enhanced in your clinic where you need to slowly infuse angiotensin II in the blood to increase systolic blood pressure. It will allow you to treat tumours with an extreme hypoxic condition.
Equipment which allows such advanced nanotechnology in India cost substantially and may require external financial assistance such as loans for doctors to adequately finance an up-gradation of your clinic to the latest technologies.
2. Tumour targeting
While EPR effect enables the nanoparticles to travel across vascular regions and into the tumour region. It is thereby followed by its diffusion throughout such tissue. Active tumour targeting enables the drug particles such as diffusion into cellular compartments through particle modification which involves antibodies, peptides, affibodies, or aptamers.
The key role of active tumour targeting is to enhance drug accumulation. These nanoparticles are incorporated with ligands which are absorbed with the endothelial cell receptors. This methodology allows targeting both the affected vascular region as well as the cancer cells.
The efficacy of such nanotechnology in India heavily relies on the effectiveness of EPR. In case you do not have equipment which allows efficient EPR effect, it is one of the reasons to upgrade your medical equipment today.
Passing through barriers
Although the methodology of EPR and delivery of nanoparticles across blood vessels and tissues sounds convenient, the tumour microenvironment poses considerable threat in the form of tissue barriers.
To reduce or diminish the interstitial fluid pressure, medical practitioners use ECM-targeting, which normalises the vasculature inside the tumour microenvironment. A machine capable of ECM targeting is expensive which is why a doctor’s loan can help you buy the best medical tools and equipment for your clinic and remain competitive in the growing market of nanotechnology in India.
Nanotechnology is a unique measure towards developing a cure, as not only does it allow cancer detection at its early stages, but also allows medical practitioners to concentrate at the affected region and treat the same effectively.